Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses.

@article{Lscher2004RegulationOG,
  title={Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses.},
  author={Bernhard L{\"u}scher and Cheryl A. Keller},
  journal={Pharmacology & therapeutics},
  year={2004},
  volume={102 3},
  pages={195-221}
}
Neural inhibition in the brain is mainly mediated by ionotropic gamma-aminobutyric acid type A (GABA(A)) receptors. Different subtypes of these receptors, distinguished by their subunit composition, are either concentrated at postsynaptic sites where they mediate phasic inhibition or found at perisynaptic and extrasynaptic locations where they prolong phasic inhibition and mediate tonic inhibition, respectively. Of special interest are mechanisms that modulate the stability and function of… CONTINUE READING
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