Regulation of GABAA receptor function by protein kinase C phosphorylation

@article{Krishek1994RegulationOG,
  title={Regulation of GABAA receptor function by protein kinase C phosphorylation},
  author={Belinda J. Krishek and Xinmin M. Xie and Craig Blackstone and Richard L. Huganir and Stephen James Moss and Trevor G Smart},
  journal={Neuron},
  year={1994},
  volume={12},
  pages={1081-1095}
}
GABAA receptors possess consensus sequences for phosphorylation by PKC that are located on the presumed intracellular domains of beta and gamma 2 subunits. PKC phosphorylation sites were analyzed using purified receptor subunits and were located on up to 3 serine residues in beta 1 and gamma 2 subunits. The role of phosphorylation in receptor function was studied using recombinant receptors expressed in kidney cells and Xenopus oocytes and was compared with native neuronal GABAA receptors. For… CONTINUE READING
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