Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents

@article{UusiOukari2010RegulationOG,
  title={Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents},
  author={Mikko Uusi-Oukari and Esa R. Korpi},
  journal={Pharmacological Reviews},
  year={2010},
  volume={62},
  pages={135 - 97}
}
The γ-aminobutyric acid (GABA) type A receptor system, the main fast-acting inhibitory neurotransmitter system in the brain, is the pharmacological target for many drugs used clinically to treat, for example, anxiety disorders and epilepsy, and to induce and maintain sedation, sleep, and anesthesia. These drugs facilitate the function of pentameric GABAA receptors that exhibit widespread expression in all brain regions and large structural and pharmacological heterogeneity as a result of… Expand
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