Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.

@article{Wang2014RegulationOG,
  title={Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.},
  author={Yiping Wang and Li-sha Zhou and Yu-Zheng Zhao and Shi-wen Wang and Lei-Lei Chen and Lixia Liu and Zhiqiang Ling and Fu-jun Hu and Yi-ping Sun and Jing-ye Zhang and Chen Yang and Yi Liang and Yue Xiong and Kun Liang Guan and Dan Ye},
  journal={The EMBO journal},
  year={2014},
  volume={33 12},
  pages={1304-20}
}
Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant. G6PD deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. Here, we show that G6PD is negatively regulated by acetylation on lysine 403 (K403), an evolutionarily conserved residue. The K403 acetylated G6PD is incapable of forming active… CONTINUE READING

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