Regulation of G1/S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR).

Abstract

We previously reported that all-trans retinoic acid (RA) and fenretinide (4HPR) suppress HL-60 leukemia cell growth and cause partial cell arrest in the G1-to-S phase. Moreover, 4HPR but not RA induces apoptosis in HL-60 cells. To investigate further the observed biological effects, cyclin D1 and cdk4 expression and the level of phosphorylation of the… (More)

Topics

  • Presentations referencing similar topics