Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.

@article{Ammer1991RegulationOG,
  title={Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.},
  author={Hermann Ammer and L R Nice and Jingyu Lang and R{\"u}diger Schulz},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={258 3},
  pages={790-6}
}
G proteins have been implicated in the development of opioid dependence of the guinea pig myenteric plexus as chronic fentanyl elevates G0/i alpha and pertussis toxin prevents this phenomenon. Therefore, the present study investigates G proteins more closely in this peripheral nerve plexus after chronic exposure to addictive drugs of the opiate and nonopiate type. After 6 days of treatment with either the mu receptor ligand fentanyl, the kappa- agonist U-50,488H or the alpha-2 adrenergic… CONTINUE READING