Regulation of G protein function by an effector in GTP-dependent signal transduction. An inhibitory subunit of cGMP phosphodiesterase inhibits GTP hydrolysis by transducin in vertebrate rod photoreceptors.

@article{Yamazaki1993RegulationOG,
  title={Regulation of G protein function by an effector in GTP-dependent signal transduction. An inhibitory subunit of cGMP phosphodiesterase inhibits GTP hydrolysis by transducin in vertebrate rod photoreceptors.},
  author={Akio Yamazaki and Matsuyo Yamazaki and Shigeru Tsuboi and Akio Kishigami and K O Umbarger and L D Hutson and W T Madland and Fumiaki Hayashi},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 12},
  pages={8899-907}
}
The regulation of cGMP phosphodiesterase in vertebrate rod photoreceptors is a typical G protein-dependent signal transduction mechanism. The interaction of P gamma, an inhibitory subunit of cGMP phosphodiesterase, with transducin alpha subunit (T alpha) is essential for the activation of cGMP phosphodiesterase. It has been shown that, in a homogenized preparation of frog (Rana catesbeiana) rods, P gamma interacts with GTP.T alpha and remains tightly bound to GDP.T alpha after GTP hydrolysis on… CONTINUE READING