Regulation of G-protein-coupled signaling pathways in allergic inflammation.

  title={Regulation of G-protein-coupled signaling pathways in allergic inflammation.},
  author={Kirk M. Druey},
  journal={Immunologic research},
  volume={43 1-3},
Allergic diseases such as asthma are elicited by maladaptive activation of immune cells such as mast cells and lymphocytes by otherwise innocuous allergens. The numerous mediators secreted by such cells promote both acute inflammation and, in many instances, chronic tissue remodeling. Most of these compounds exert their effects on end-organ targets such as epithelial and endothelial cells and airway smooth muscle by activating G-protein-coupled receptors (GPCRs), which are by far the most… CONTINUE READING

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