Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.

@article{Ozaita1998RegulationOG,
  title={Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.},
  author={Andr{\'e}s Ozaita and Pablo V. Escrib{\'a} and Pere Ventayol and Cristina Murga and Federico Mayor and Jes{\'u}s Andr{\'e}s Garc{\'i}a-Sevilla},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 3},
  pages={1249-57}
}
The effects of opiate drugs (heroin, morphine, and methadone) on the levels of G protein-coupled receptor kinase 2 (GRK2) were studied in rat and human brain frontal cortices. The density of brain GRK2 was measured by immunoblot assays in acute and chronic opiate-treated rats as well as in opiate-dependent rats after spontaneous or naloxone-precipitated withdrawal and in human opiate addicts who had died of an opiate overdose. In postmortem brains from human addicts, total GRK2 immunoreactivity… CONTINUE READING

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