Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine.

@article{Mundell2001RegulationOG,
  title={Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine.},
  author={Stuart James Mundell and M. Ol{\'a}h and Reynold A Panettieri and Jeffrey L. Benovic and Raymond B. Penn},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={24 2},
  pages={155-63}
}
Adenosine is a mediator of bronchoconstriction in asthmatics and is believed to mediate its effects through adenosine receptor activation in inflammatory cells. In this study, we identify human airway smooth muscle (ASM) as a direct target of adenosine. Acute exposure of human ASM cultures to adenosine receptor (AR) agonists resulted in rapid accumulation of cyclic adenosine monophosphate (cAMP) with a pharmacologic profile consistent with A(2b)AR activation. Little or no evidence of A1AR or… CONTINUE READING

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