Regulation of G Proteins by Covalent Modification

@inproceedings{Jennings2010RegulationOG,
  title={Regulation of G Proteins by Covalent Modification},
  author={Benjamin C Jennings and Maurine E. Linder},
  year={2010}
}
Publisher Summary This chapter focuses on the covalent attachment of lipids to G proteins, modifications that anchor G-protein subunits to the membrane. Lipidation of G proteins is essential for their ability to propagate signals from cell surface receptors to effectors. Covalent modifications of G-protein subunits play key roles in their function, localization, and regulation. The discovery of ADP-ribosylation of G-protein α subunits by cholera and pertussis toxins provided significant… CONTINUE READING

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