Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress.

@article{Chlench2007RegulationOF,
  title={Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress.},
  author={Sven Chlench and Nigussie Mecha Disassa and Margret Hohberg and Christian Hoffmann and Theresa Pohlkamp and Gabriele Beyer and Mauro Bongrazio and Luis Da Silva-Azevedo and Oliver Baum and Axel Radlach Pries and Andreas Zakrzewicz},
  journal={FEBS letters},
  year={2007},
  volume={581 4},
  pages={673-80}
}
Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6dyn/cm(2), 24h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were… CONTINUE READING
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