Regulation of Fcgamma receptors and immunoglobulin G-mediated phagocytosis in mouse microglia.

@article{Quan2009RegulationOF,
  title={Regulation of Fcgamma receptors and immunoglobulin G-mediated phagocytosis in mouse microglia.},
  author={Yi Quan and Thomas Moeller and Jonathan R Weinstein},
  journal={Neuroscience letters},
  year={2009},
  volume={464 1},
  pages={29-33}
}
As resident macrophages in the CNS, microglia can transform from a surveillance state to an activated phenotype in response to brain injury. During this transition microglia become highly capable phagocytic cells. Invading pathogens undergo opsonization with immunoglobulins and microglia recognize these opsonized pathogens through interaction with their cognate F(c) receptors. In mice, both FcgammaRI and FcgammaRIIb receptors are involved in IgG-mediated phagocytosis of opsonzied pathogens. At… CONTINUE READING

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