Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.

@article{Beck2012RegulationOF,
  title={Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.},
  author={Erin S. Beck and Gabriel Gasque and Wendy L. Imlach and Wei Su Jiao and Ben Jiwon Choi and Peixiang Wu and Matthew L Kraushar and Brian D McCabe},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 20},
  pages={
          7058-73
        }
}
Pre-mRNA alternative splicing is an important mechanism for the generation of synaptic protein diversity, but few factors governing this process have been identified. From a screen for Drosophila mutants with aberrant synaptic development, we identified beag, a mutant with fewer synaptic boutons and decreased neurotransmitter release. Beag encodes a spliceosomal protein similar to splicing factors in humans and Caenorhabditis elegans. We find that both beag mutants and mutants of an interacting… CONTINUE READING

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