Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages.

@article{Medan2005RegulationOF,
  title={Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages.},
  author={Djordje Medan and Liying Wang and David G{\'o}mez Toledo and Bin Lu and Christian Stehlik and Bing-hua Jiang and Xianglin Shi and Yon Rojanasakul},
  journal={Journal of cellular physiology},
  year={2005},
  volume={203 1},
  pages={78-84}
}
Although reactive oxygen species (ROS) have long been suspected to play a key role in Fas (CD95)-induced cell death, the identity of specific ROS involved in this process and the relationship between apoptotic and necrotic cell death induced by Fas are largely unknown. Using electron spin resonance (ESR) spectroscopy, we showed that activation of Fas receptor by its ligand (FasL) in macrophages resulted in a rapid and transient production of hydrogen peroxide (H2O2) and hydroxyl radicals (*OH… CONTINUE READING

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