Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.

@article{Sakamaki2009RegulationOF,
  title={Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.},
  author={Jun-ichi Sakamaki and Hiroaki Daitoku and Kenji Yoshimochi and Masanao Miwa and Akiyoshi Fukamizu},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={382 3},
  pages={497-502}
}
Forkhead box O (FOXO) transcription factors play an important role in a wide range of biological processes, including cell cycle control, apoptosis, detoxification of reactive oxygen species, and gluconeogenesis through regulation of gene expression. In this study, we demonstrated that PARP-1 functions as a negative regulator of FOXO1. We showed that PARP-1… CONTINUE READING