Regulation of Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines.

@article{Tomlinson2001RegulationOE,
  title={Regulation of Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines.},
  author={J W Tomlinson and J K Moore and Mark Stuart Cooper and Iwona J. Bujalska and Mohsen Shahmanesh and Claire L Burt and Alastair J. Strain and Martin Hewison and P. M. Stewart},
  journal={Endocrinology},
  year={2001},
  volume={142 5},
  pages={1982-1989}
}
Patients with glucocorticoid excess develop central obesity, yet in simple obesity, circulating glucocorticoid levels are normal. We have suggested that the increased activity and expression of the enzyme 11b-hydroxysteroid dehydrogenase type 1 (11bHSD1) generating active cortisol from cortisone within adipose tissue may be crucial in the pathogenesis of obesity. In this study primary cultures of human hepatocytes and adipose stromal cells (ASC) were used as in vitro models to investigate the… CONTINUE READING