Regulation of Escherichia coli hemolysin E expression by H-NS and Salmonella SlyA.

@article{Wyborn2004RegulationOE,
  title={Regulation of Escherichia coli hemolysin E expression by H-NS and Salmonella SlyA.},
  author={Neil R Wyborn and Melanie R. Stapleton and Valia A Norte and Ruth E. Roberts and Jamie Grafton and Jeffrey Green},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 6},
  pages={1620-8}
}
The Escherichia coli hlyE gene (also known as clyA or sheA) codes for a novel pore-forming toxin. Previous work has shown that the global transcription factors FNR and CRP positively regulate hlyE expression by binding at the same site. Here in vivo transcription studies reveal that FNR occupies the hlyE promoter more frequently than CRP, providing a mechanism for the moderate upregulation of hlyE expression in response to two distinct environmental signals (oxygen and glucose starvation). It… CONTINUE READING

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