Regulation of Epithelial Na+ Permeability by Protein Kinase C is Tissue Specific

  title={Regulation of Epithelial Na+ Permeability by Protein Kinase C is Tissue Specific},
  author={Michael L Chalfant and J. M. Civan and Kim Peterson-Yantorno and Donald R Dibona and Thomas G. O'Brien and Mortimer M. Civan},
  journal={The Journal of Membrane Biology},
Protein kinase C (PKC) is a major regulator of a broad range of cellular functions. Activation of PKC has been reported to stimulate Na+ transport across frog skin epithelium by increasing the apical Na+ permeability. This positive natriferic response has not been observed with other epithelial preparations, and could reflect the specific experimental conditions of different laboratories, or species or organ specificity of the response to PKC. In the present study, measurements were conducted… CONTINUE READING
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