Regulation of Early Adipose Commitment by Zfp521

  title={Regulation of Early Adipose Commitment by Zfp521},
  author={Sona Kang and Peter {\AA}kerblad and Riku Kiviranta and Rana K Gupta and Shingo Kajimura and Michael J. Griffin and Jie Min and Roland Baron and Evan D Rosen},
  booktitle={PLoS biology},
While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently discovered that zinc finger protein 423 (Zfp423) is an early actor in adipose determination. Here, we show that a close paralog of Zfp423, Zfp521, acts as a key regulator of adipose commitment and differentiation in vitro and in vivo. Zfp521 exerts its actions… CONTINUE READING
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