Regulation of ES cell differentiation by functional and conformational modulation of p53.

@article{Sabapathy1997RegulationOE,
  title={Regulation of ES cell differentiation by functional and conformational modulation of p53.},
  author={Kanaga T. Sabapathy and Martina Klemm and Rudolf Jaenisch and Erwin F Wagner},
  journal={The EMBO journal},
  year={1997},
  volume={16 20},
  pages={6217-29}
}
Embryonic stem (ES) cell lines were used to examine the role of p53 during in vitro differentiation. Undifferentiated ES cells express high levels of p53 exclusively in the wild-type conformation, immunoprecipitable by monoclonal antibody PAb246, and p53 was found to be functionally active as determined by its ability to bind DNA specifically and to activate transcription of target genes. Differentiation in vitro resulted in a decrease in the levels of p53 and in a shift in its conformational… CONTINUE READING
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  • E. Gottlieb, R. Haffner, T. von Ruden, E. F. Wagner, M. Oren
  • EMBO J.,
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