Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.

Abstract

ERK5 is involved in proliferation of vascular smooth muscle cells (VSMC). The proliferative actions of insulin and angiotensin-II (A-II) in VSMC are mediated in part by ERK1/2. We hypothesized that insulin and A-II also regulate ERK5 activity in VSMC. Acute treatment (<60min) with insulin or A-II increased phosphorylation of ERK1/2 at 15min and ERK5 at 5min… (More)

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Cite this paper

@article{Sharma2007RegulationOE, title={Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.}, author={Girish Sharma and Marc Lee Goalstone}, journal={Biochemical and biophysical research communications}, year={2007}, volume={354 4}, pages={1078-83} }