Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.

@article{Arnette2003RegulationOE,
  title={Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.},
  author={Don Arnette and Tara Beers Gibson and Michael C Lawrence and Bridgette G. January and Shih Khoo and Kathleen McGlynn and Colleen A. Vanderbilt and Melanie H Cobb},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 35},
  pages={32517-25}
}
We showed previously that ERK1/2 were activated by glucose and amino acids in pancreatic beta cells. Here we examine and compare signaling events that are necessary for ERK1/2 activation by glucose and other stimuli in beta cells. We find that agents that interrupt Ca2+ signaling by a variety of mechanisms interfere with glucose- and glucagon-like peptide… CONTINUE READING