Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain.

Abstract

Metabotropic (slow) and ionotropic (fast) neurotransmission are integrated by intracellular signal transduction mechanisms involving protein phosphorylation/dephosphorylation to achieve experience-dependent alterations in brain circuitry. ERK is an important effector of both slow and fast forms of neurotransmission and has been implicated in normal brain… (More)
DOI: 10.1074/jbc.M115.654897

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