Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis

  title={Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis},
  author={Trung Q Vu and Pran K Datta},
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance cell polarity and cell-cell contact, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. In this review, we discuss recent studies exploring novel regulation mechanisms of EMT in CRC, including the identification of new CRC EMT regulators. Upregulation of inducers can… CONTINUE READING
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