Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1

  title={Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1},
  author={Hyung Don Ryoo and Andreas Bergmann and Hedva Gonen and Aaron Ciechanover and Hermann Steller},
  journal={Nature Cell Biology},
Cell death in higher organisms is negatively regulated by Inhibitor of Apoptosis Proteins (IAPs), which contain a ubiquitin ligase motif, but how ubiquitin-mediated protein degradation is regulated during apoptosis is poorly understood. Here, we report that Drosophila melanogaster IAP1 (DIAP1) auto-ubiquitination and degradation is actively regulated by Reaper (Rpr) and UBCD1. We show that Rpr, but not Hid (head involution defective), promotes significant DIAP1 degradation. Rpr-mediated DIAP1… CONTINUE READING
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