Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

@article{Kahlig2006RegulationOD,
  title={Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine},
  author={Kristopher M. Kahlig and Brandon J. Lute and Yuqiang Wei and C. Loland and U. Gether and J. Javitch and A. Galli},
  journal={Molecular Pharmacology},
  year={2006},
  volume={70},
  pages={542 - 548}
}
  • Kristopher M. Kahlig, Brandon J. Lute, +4 authors A. Galli
  • Published 2006
  • Chemistry, Medicine
  • Molecular Pharmacology
  • The dopamine (DA) transporter (DAT) mediates the removal of released DA. DAT is the major molecular target responsible for the rewarding properties and abuse potential of the psychostimulant amphetamine (AMPH). AMPH has been shown to reduce the number of DATs at the cell surface, and this AMPH-induced cell surface DAT redistribution may result in long-lasting changes in DA homeostasis. The molecular mechanism by which AMPH induces trafficking is not clear. Because AMPH is a substrate, we do not… CONTINUE READING
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