Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

  title={Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine},
  author={Kristopher M. Kahlig and Brandon J. Lute and Yuqiang Wei and C. Loland and U. Gether and J. Javitch and A. Galli},
  journal={Molecular Pharmacology},
  pages={542 - 548}
  • Kristopher M. Kahlig, Brandon J. Lute, +4 authors A. Galli
  • Published 2006
  • Chemistry, Medicine
  • Molecular Pharmacology
  • The dopamine (DA) transporter (DAT) mediates the removal of released DA. DAT is the major molecular target responsible for the rewarding properties and abuse potential of the psychostimulant amphetamine (AMPH). AMPH has been shown to reduce the number of DATs at the cell surface, and this AMPH-induced cell surface DAT redistribution may result in long-lasting changes in DA homeostasis. The molecular mechanism by which AMPH induces trafficking is not clear. Because AMPH is a substrate, we do not… CONTINUE READING
    70 Citations

    Figures and Topics from this paper

    Insights in how amphetamine ROCKs (Rho-associated containing kinase) membrane protein trafficking
    • 1
    • PDF
    Simple transporter trafficking model for amphetamine‐induced dopamine efflux
    • 9
    • PDF
    Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine
    • 47
    • Highly Influenced
    • PDF
    Ethanol Alters Endosomal Recycling of Human Dopamine Transporters
    • 13
    • PDF
    Trafficking of dopamine transporters in psychostimulant actions.
    • 76
    Substrates dissociate dopamine transporter oligomers
    • 40
    Dopamine transporter trafficking: rapid response on demand.
    • 34
    • Highly Influenced


    Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.
    • C. Saunders, J. Ferrer, +7 authors A. Galli
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 382
    • PDF
    Amphetamine Regulation of Dopamine Transport
    • 75
    • PDF
    N-Terminal Phosphorylation of the Dopamine Transporter Is Required for Amphetamine-Induced Efflux
    • 224
    • PDF
    Akt Is Essential for Insulin Modulation of Amphetamine-Induced Human Dopamine Transporter Cell-Surface Redistribution
    • 139
    • PDF
    Membrane Trafficking Regulates the Activity of the Human Dopamine Transporter
    • 368
    • PDF
    PI 3‐kinase regulation of dopamine uptake
    • 194
    Regulated Trafficking of the Human Dopamine Transporter
    • 349
    • Highly Influential
    • PDF
    Oligomerization and Trafficking of the Human Dopamine Transporter
    • 266
    • PDF
    The Dopamine Transporter Constitutively Internalizes and Recycles in a Protein Kinase C-regulated Manner in Stably Transfected PC12 Cell Lines*
    • 237
    • Highly Influential
    • PDF