Regulation of Dio2 gene expression by thyroid hormones in normal and type 1 deiodinase-deficient C3H mice.


The C3H/HeJ mouse presents an inherited type 1 deiodinase (D1) deficiency that results in elevated serum thyroxine (T(4)), whereas TSH and tri-iodothyronine (T(3)) concentrations are normal when compared with those in the C57BL/6J strain. Here, we evaluated the expression of the type 2 (D2), the other T(4)-activating enzyme, in C3H mice. A comparative… (More)


8 Figures and Tables

Slides referencing similar topics