Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation.

  title={Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation.},
  author={Paula G Ulery and Eric J Nestler},
  journal={The European journal of neuroscience},
  volume={25 1},
The transcription factor, DeltaFosB, is an important mediator of the long-term plasticity induced in brain by chronic exposure to drugs of abuse, stress, or several other psychoactive stimuli. We have previously demonstrated that the casein kinase 2 (CK2)-mediated phosphorylation of a highly conserved N-terminal serine (Ser27) plays a critical role in regulating DeltaFosB's unusual stability, while it does not affect that of the full-length FosB protein. In the present study, we analysed… CONTINUE READING


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