Regulation of DNA replication on subchromosomal units of mammalian cells

  title={Regulation of DNA replication on subchromosomal units of mammalian cells},
  author={Roger Hand},
  journal={The Journal of Cell Biology},
  pages={89 - 97}
  • Roger Hand
  • Published 1975 in The Journal of cell biology
The regulation of DNA replication at a subchromosomal level in mammalian cells has been investigated. DNA fiber autoradiographs were prepared from mouse L-929 cells pulse labeled with (3H)thymidine. Initiation events and subsequent chain growth occurring over short stretches (up to three replication units in length) of chromosomal DNA were analyzed. The results show that adjacent units usually initiate replication synchronously and that this synchrony is related to the proximity of initiation… CONTINUE READING

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