Regulation of DNA replication by the S-phase DNA damage checkpoint

@article{Willis2009RegulationOD,
  title={Regulation of DNA replication by the S-phase DNA damage checkpoint},
  author={Nicholas A Willis and Nicholas Rhind},
  journal={Cell Division},
  year={2009},
  volume={4},
  pages={13 - 13}
}
Cells slow replication in response to DNA damage. This slowing was the first DNA damage checkpoint response discovered and its study led to the discovery of the central checkpoint kinase, Ataxia Telangiectasia Mutated (ATM). Nonetheless, the manner by which the S-phase DNA damage checkpoint slows replication is still unclear. The checkpoint could slow bulk replication by inhibiting replication origin firing or slowing replication fork progression, and both mechanisms appear to be used. However… CONTINUE READING