Regulation of DNA replication by ATR: signaling in response to DNA intermediates.

@article{Shechter2004RegulationOD,
  title={Regulation of DNA replication by ATR: signaling in response to DNA intermediates.},
  author={David Shechter and Vincenzo Costanzo and J -C. Gautier},
  journal={DNA repair},
  year={2004},
  volume={3 8-9},
  pages={901-8}
}
The nuclear protein kinase ATR controls S-phase progression in response to DNA damage and replication fork stalling, including damage caused by ultraviolet irradiation, hyperoxia, and replication inhibitors like aphidicolin and hydroxyurea. ATR activation and substrate specificity require the presence of adapter and mediator molecules, ultimately resulting… CONTINUE READING