Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.

@article{Dou2010RegulationOD,
  title={Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.},
  author={Hong Dou and Chao Huang and Melissa M. Singh and Phillip B. Carpenter and Edward T. H. Yeh},
  journal={Molecular cell},
  year={2010},
  volume={39 3},
  pages={333-45}
}
The replication protein A complex (RPA) plays a crucial role in DNA replication and damage response. However, it is not known whether this complex is regulated by the SUMOylation pathway. Here, we show that the 70 kDa subunit of RPA (RPA70) associates with a Sentrin/SUMO-specific protease, SENP6, in the nucleus to maintain RPA70 in a hypoSUMOylated state during S phase. Campothecin (CPT), an inducer of replication stress, dissociates SENP6 from RPA70, allowing RPA70 to be modified by a small… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 61 references

Mechanism of eukaryotic homologous recombination.

Annual review of biochemistry • 2008
View 5 Excerpts
Highly Influenced

RecA

R. Galletto, S. C. Kowalczykowski
Curr. Biol. 17, R395–R397. • 2007
View 3 Excerpts
Highly Influenced

Radiation-induced DNA damage responses.

Radiation protection dosimetry • 2006
View 5 Excerpts
Highly Influenced

SUSP1 antagonizes formation of highly SUMO2/3-conjugated species

The Journal of cell biology • 2006
View 4 Excerpts
Highly Influenced

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