Regulation of DNA repair gene expression in human cancer cell lines.

  title={Regulation of DNA repair gene expression in human cancer cell lines.},
  author={Claire J McGurk and Michele Cummings and Beate K{\"o}berle and John A. Hartley and R Timothy D Oliver and John R. W. Masters},
  journal={Journal of cellular biochemistry},
  volume={97 5},
Although most advanced cancers are incurable, the majority of testicular germ cell tumors can be cured using cisplatin-based combination chemotherapy. The nucleotide excision repair (NER) pathway removes most DNA adducts produced by cisplatin, and the low levels of NER in testis tumor cells may explain why these cancers are curable. Three NER proteins: ERCC1, XPF, and XPA, are present at low levels in testis tumor cell lines, and addition of these proteins to protein extracts of testis tumor… CONTINUE READING


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