Regulation of DNA double-strand break repair pathway choice

@article{Shrivastav2008RegulationOD,
  title={Regulation of DNA double-strand break repair pathway choice},
  author={Meena Shrivastav and Leyma P. De Haro and Jac A. Nickoloff},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={134-147}
}
DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide variety of genetic alterations including large- or small-scale deletions, loss of heterozygosity, translocations, and chromosome loss. [...] Key Result While most DSB repair proteins appear to function exclusively in NHEJ or HR, a number of proteins influence both pathways, including the MRE11/RAD50/NBS1(XRS2) complex, BRCA1, histone H2AX, PARP-1, RAD18, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and ATM…Expand Abstract

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Life and Death

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.