Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.

  title={Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.},
  author={Zengqiang Yuan and Yinyin Huang and Takatoshi Ishiko and Surender Kharbanda and Ralph Weichselbaum and Donald Kufe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 4},
Activation of the c-Abl protein tyrosine kinase by certain DNA-damaging agents contributes to downregulation of Cdk2 and G1 arrest by a p53-dependent mechanism. The present work investigates the potential role of c-Abl in apoptosis induced by DNA damage. Transient transfection studies with wild-type, but not kinase-inactive, c-Abl demonstrate induction of apoptosis. Cells that stably express inactive c-Abl exhibit resistance to ionizing radiation-induced loss of clonogenic survival and… CONTINUE READING

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