Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome

@inproceedings{Gadaleta2017RegulationOD,
  title={Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome},
  author={Mariana C. Gadaleta and Eishi Noguchi},
  booktitle={Genes},
  year={2017}
}
All living organisms need to duplicate their genetic information while protecting it from unwanted mutations, which can lead to genetic disorders and cancer development. Inaccuracies during DNA replication are the major cause of genomic instability, as replication forks are prone to stalling and collapse, resulting in DNA damage. The presence of exogenous DNA damaging agents as well as endogenous difficult-to-replicate DNA regions containing DNA-protein complexes, repetitive DNA, secondary DNA… CONTINUE READING