Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation.

@article{Jiang2010RegulationOD,
  title={Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: implication for skin photoprotection against UVA radiation.},
  author={Shan Jiang and Xiao-Ming Liu and Xin Dai and Qiong Zhou and Tie-Chi Lei and Friedrich Beermann and Kazumasa Wakamatsu and Shi-zheng Xu},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 9},
  pages={1144-51}
}
Dopachrome tautomerase (Dct) is a critical enzyme in the melanogenesis pathway that isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyindole (DHI) polymer in eumelanin. To investigate whether Dct inactivation affects skin photoprotection against ultraviolet radiation, we examined levels of reactive oxygen species (ROS), sunburn cell formation, epidermal cell apoptosis, and… CONTINUE READING