Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinol.

  title={Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinol.},
  author={Anders Borgkvist and Daniel Marcellino and Kjell Fuxe and Paul Greengard and Gilberto Fisone},
  volume={54 1},
CB1 receptor agonists increase the state of phosphorylation of the dopamine and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) at the cAMP-dependent protein kinase site, Thr 34. This effect, which occurs in the medium spiny neurons of the striatum, has been proposed to mediate the motor depressant action of cannabinoids. In this study, we have examined the effect produced by systemic administration of Delta(9)-tetrahydrocannabinol (THC), the major component of marihuana and hashish, on… CONTINUE READING


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