Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.

@article{Pierce2001RegulationOD,
  title={Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.},
  author={Sarah B Pierce and Max Costa and Robert Wisotzkey and S Devadhar and S A Homburger and Andrew Roy Buchman and Kimberly Carr Ferguson and Jennifer K. Heller and Donna M Platt and Amy Pasquinelli and Lang Xia Liu and Stephen Kohl Doberstein and Gary Ruvkun},
  journal={Genes & development},
  year={2001},
  volume={15 6},
  pages={
          672-86
        }
}
The activity of the DAF-2 insulin-like receptor is required for Caenorhabditis elegans reproductive growth and normal adult life span. Informatic analysis identified 37 C. elegans genes predicted to encode insulin-like peptides. Many of these genes are divergent insulin superfamily members, and many are clustered, indicating recent diversification of the family. The ins genes are primarily expressed in neurons, including sensory neurons, a subset of which are required for reproductive… CONTINUE READING

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