Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.

  title={Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.},
  author={Isao Tamura and Joel Rosenbloom and Edward J. Macarak and Brahim Chaqour},
  journal={American journal of physiology. Cell physiology},
  volume={281 5},
The cysteine-rich protein 61 (Cyr61) is a signaling molecule with functions in cell migration, adhesion, and proliferation. This protein is encoded by an immediate early gene whose expression is mainly induced by serum growth factors. Here we show that Cyr61 mRNA levels increase sharply in response to cyclic mechanical stretch applied to cultured bladder smooth muscle cells. Stretch-induced changes of Cyr61 transcripts were transient and accompanied by an increase of the encoded protein that… CONTINUE READING
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