Regulation of Cx45 hemichannels mediated by extracellular and intracellular calcium

  title={Regulation of Cx45 hemichannels mediated by extracellular and intracellular calcium},
  author={Patrick Bader and Robert Weingart and Marcel Egger},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
Connexin45 (Cx45) hemichannels (HCs) open in the absence of Ca2+ and close in its presence. To elucidate the underlying mechanisms, we examined the role of extra- and intracellular Ca2+ on the electrical properties of HCs. Experiments were performed on HeLa cells expressing Cx45 using electrical (voltage clamp) and optical (Ca2+ imaging) methods. HCs exhibit a time- and voltage-dependent current (I hc), activating with depolarization and inactivating with hyperpolarization. Elevation of [Ca2+]o… CONTINUE READING


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Molecular basis of calcium regulation in connexin-32 hemichannels

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  • Proc Natl Acad Sci U S A
  • 2003
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