Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.

  title={Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.},
  author={Dennis M Klinman and Rainald A. Zeuner and Hiroshi Yamada and Mayda Gursel and Debbie Currie and Ihsan Gursel},
  journal={Annals of the New York Academy of Sciences},
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated "CpG motifs" stimulate an innate immune response characterized by the production of cytokines, chemokines, and polyreactive Igs that promote host survival following infectious challenge. Yet CpG-driven immune activation can have deleterious consequences, such as increasing the host's susceptibility to autoimmune disease. The immunomodulatory activity of CpG DNA can be blocked by DNA containing "suppressive" motifs… CONTINUE READING


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