Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.

@article{Khubieh2016RegulationOC,
  title={Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.},
  author={Ayah Khubieh and St{\'e}phanie Ratt{\'e} and Milad Lankarany and Steven A. Prescott},
  journal={Cerebral cortex},
  year={2016},
  volume={26 8},
  pages={
          3357-69
        }
}
The cortex encodes a broad range of inputs. This breadth of operation requires sensitivity to weak inputs yet non-saturating responses to strong inputs. If individual pyramidal neurons were to have a narrow dynamic range, as previously claimed, then staggered all-or-none recruitment of those neurons would be necessary for the population to achieve a broad dynamic range. Contrary to this explanation, we show here through dynamic clamp experiments in vitro and computer simulations that pyramidal… CONTINUE READING
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