Regulation of Corepressor Function by Nuclear NADH

  title={Regulation of Corepressor Function by Nuclear NADH},
  author={Q. Zhang and David W. Piston and R. Goodman},
  pages={1895 - 1897}
  • Q. Zhang, David W. Piston, R. Goodman
  • Published 2002
  • Biology, Medicine
  • Science
  • The corepressor CtBP (carboxyl-terminal binding protein) is involved in transcriptional pathways important for development, cell cycle regulation, and transformation. We demonstrate that CtBP binding to cellular and viral transcriptional repressors is regulated by the nicotinamide adenine dinucleotides NAD+ and NADH, with NADH being two to three orders of magnitude more effective. Levels of free nuclear nicotinamide adenine dinucleotides, determined using two-photon microscopy, correspond to… CONTINUE READING
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