Regulation of Corepressor Function by Nuclear NADH

@article{Zhang2002RegulationOC,
  title={Regulation of Corepressor Function by Nuclear NADH},
  author={Q. Zhang and David W. Piston and R. Goodman},
  journal={Science},
  year={2002},
  volume={295},
  pages={1895 - 1897}
}
  • Q. Zhang, David W. Piston, R. Goodman
  • Published 2002
  • Biology, Medicine
  • Science
  • The corepressor CtBP (carboxyl-terminal binding protein) is involved in transcriptional pathways important for development, cell cycle regulation, and transformation. We demonstrate that CtBP binding to cellular and viral transcriptional repressors is regulated by the nicotinamide adenine dinucleotides NAD+ and NADH, with NADH being two to three orders of magnitude more effective. Levels of free nuclear nicotinamide adenine dinucleotides, determined using two-photon microscopy, correspond to… CONTINUE READING
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    References

    SHOWING 1-10 OF 20 REFERENCES
    ZEB represses transcription through interaction with the corepressor CtBP.
    • A. A. Postigo, D. Dean
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 252
    • PDF
    Transcriptional coregulators in development.
    • 240
    The CtBP family: enigmatic and enzymatic transcriptional co‐repressors
    • J. Turner, M. Crossley
    • Medicine, Biology
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2001
    • 172
    The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
    • 854
    • PDF