Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting , cAMP , Hepatocyte Nuclear Factor , and the Coactivator Peroxisome Proliferator-activated Receptor Coactivator-1 *

Animal studies reveal that fasting and caloric restriction produce increased activity of specific metabolic pathways involved in resistance to weight loss in liver. Evidence suggests that this phenomenon may in part occur through the action of the constitutive androstane receptor (CAR, NR1I3). Currently, the precisemolecularmechanisms that activate… CONTINUE READING