Regulation of Connexin Hemichannels by Monovalent Cations

  title={Regulation of Connexin Hemichannels by Monovalent Cations},
  author={Miduturu Srinivas and Diany Paola Calderon and Jack Kronengold and Vytas K. Verselis},
  journal={The Journal of General Physiology},
  pages={67 - 75}
Opening of connexin hemichannels in the plasma membrane is highly regulated. Generally, depolarization and reduced extracellular Ca2+ promote hemichannel opening. Here we show that hemichannels formed of Cx50, a principal lens connexin, exhibit a novel form of regulation characterized by extraordinary sensitivity to extracellular monovalent cations. Replacement of extracellular Na+ with K+, while maintaining extracellular Ca2+ constant, resulted in >10-fold potentiation of Cx50 hemichannel… CONTINUE READING


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Palmer served as editor

G Lawrence
Palmer served as editor • 2005

Connexins are mechanosensitive.

American journal of physiology. Cell physiology • 2004
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