Regulation of Clostridium difficile spore germination by the CspA pseudoprotease domain.

@article{Kevorkian2016RegulationOC,
  title={Regulation of Clostridium difficile spore germination by the CspA pseudoprotease domain.},
  author={Yuzo Kevorkian and David J. Shirley and Aimee Shen},
  journal={Biochimie},
  year={2016},
  volume={122},
  pages={243-54}
}
Clostridium difficile is a spore-forming obligate anaerobe that is a leading cause of healthcare-associated infections. C. difficile infections begin when its metabolically dormant spores germinate in the gut of susceptible individuals. Binding of bile salt germinants to the Csp family pseudoprotease CspC triggers a proteolytic signaling cascade consisting of the Csp family protease CspB and the cortex hydrolase SleC. Conserved across many of the Clostridia, Csp proteases are subtilisin-like… CONTINUE READING
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