Regulation of Cl- permeability in normal and cystic fibrosis sweat duct cells.

@article{Ram1990RegulationOC,
  title={Regulation of Cl- permeability in normal and cystic fibrosis sweat duct cells.},
  author={S J Ram and Merle L. Weaver and Kevin L. Kirk},
  journal={The American journal of physiology},
  year={1990},
  volume={259 5 Pt 1},
  pages={C842-6}
}
Reabsorptive cells of the human sweat gland normally exhibit a high basal Cl- permeability but are markedly impermeable to Cl- in cystic fibrosis (CF). We examined the possibility that the reduced basal Cl- permeability of CF sweat duct cells in primary culture is due to a defective regulation of plasma membrane Cl- permeability by prostaglandin E2 (PGE2), which is endogenously produced by cultured sweat duct cells. The macroscopic Cl- permeabilities of normal and CF sweat duct cells were… CONTINUE READING