Regulation of Cl- channels by multifunctional CaM kinase.

  title={Regulation of Cl- channels by multifunctional CaM kinase.},
  author={Ikuo Nishimoto and John J. Wagner and Howard F Schulman and Phyllis Gardner},
  volume={6 4},
cAMP kinase has been shown to mediate the cAMP pathway for regulation of Cl- channels in lymphocytes, but the mediator of an alternative, Ca2+ pathway has not been identified. We show here that Ca2+ ionophore activates Cl- currents in cell-attached and whole-cell patch-clamp recordings of Jurkat T lymphocytes, but this activation is not direct. The effect of Ca2+ ionophore on whole-cell Cl- currents is inhibited by a specific peptide inhibitor of multifunctional Ca2+/calmodulin-dependent… CONTINUE READING

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